Interactions between vitamins and dietary phytoestrogens in the treatment of prostatic disease.

Objectives:

The objective of this study is to determine the effects and interactions that vitamins A, D, and E and soy phytoestrogens have on prostate cancer cell lines, prostate tumors, and the normal prostate of animals which are supplemented with these compounds.

Specific Aims:

1. To examine the effects of soy diets with supplementation of vitamin A, D, and E
on the prostate of male rats.

2. To examine the effects of vitamins A, D, and E, and soy phytoestrogens on prostate cell proliferation and programmed cell death (apoptosis) alone and in combination with each other.

3. To examine the effects of soy diets with supplementation of vitamin A, D, and E on prostate tumors transplanted into immunosuppressed mice.

4. To determine the effects of vitamins A, D, and E, and soy phytoestrogens on the transcriptional machinery of retinoic acid (vitamin A), vitamin D, estrogen and androgen action in prostate cancer cell lines.